Selected publications

Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome. Soares E, Xu Q, Li Q, Qu J, Zheng Y, Raeven HHM, Brandao KO, Petit I, van den Akker WMR, van Heeringen SJ, Aberdam D, Tang F, Zhou H. Proc Natl Acad Sci U S A. 2019 116 (35):17361-17370. PMID:31413199

p63 cooperates with CTCF to modulate chromatin architecture in skin keratinocytes. Qu J, Yi G, Zhou H. Epigenetics Chromatin. 2019 Jun 4;12(1):31. PMID:31164150

Mutant p63 affects epidermal cell identity through rewiring the enhancer landscape. Qu J, Tanis SEJ, Smits JPH, Kouwenhoven EN, Oti M, van den Bogaard EH, Logie C, Stunnenberg HG, van Bokhoven H, Mulder KW, Zhou HCell Rep. 2018 Dec 18;25(12):3490-3503.e4. PMID30566872

Master regulatory role of p63 in epidermal development and disease.  Soares E, Zhou H. Cell Mol Life Sci. 2018;75 (7):1179-1190. PMID: 29103147

Identification of a de novo variant in CHUK in a patient with an EEC/AEC syndrome-like phenotype and hypogammaglobulinemia. Khandelwal KD, Ockeloen CW, Venselaar H, Boulanger C, Brichard B, Sokal E, Pfundt R, Rinne T, van Beusekom E, Bloemen M, Vriend G, Revencu N, Carels CEL, van Bokhoven H, Zhou H. Am J Med Genet A. 2017 May 17. PMID:28513979

All publications

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  2. Klionsky, DJ, Abdel-Aziz, AK, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S et al.. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021;17 (1):1-382. doi: 10.1080/15548627.2020.1797280. PubMed PMID:33634751 PubMed Central PMC7996087.
  3. Osterburg, C, Osterburg, S, Zhou, H, Missero, C, Dötsch, V. Isoform-Specific Roles of Mutant p63 in Human Diseases. Cancers (Basel). 2021;13 (3):. doi: 10.3390/cancers13030536. PubMed PMID:33572532 PubMed Central PMC7866788.
  4. Smits, JGA, Qu, J, Niehues, H, Zhou, H. Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis. J Vis Exp. 2020; (159):. doi: 10.3791/60905. PubMed PMID:32478738 .
  5. COVIDSurg Collaborative. Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans. Br J Surg. 2020;107 (11):1440-1449. doi: 10.1002/bjs.11746. PubMed PMID:32395848 PubMed Central PMC7272903.
  6. Frega, M, Selten, M, Mossink, B, Keller, JM, Linda, K, Moerschen, R et al.. Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype. Cell Rep. 2020;30 (1):173-186.e6. doi: 10.1016/j.celrep.2019.12.002. PubMed PMID:31914384 .
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  8. Mammadova, A, Carels, CEL, Zhou, J, Gilissen, C, Helmich, MPAC, Bian, Z et al.. Deregulated Adhesion Program in Palatal Keratinocytes of Orofacial Cleft Patients. Genes (Basel). 2019;10 (11):. doi: 10.3390/genes10110836. PubMed PMID:31652793 PubMed Central PMC6895790.
  9. Pitzius, S, Osterburg, C, Gebel, J, Tascher, G, Schäfer, B, Zhou, H et al.. TA*p63 and GTAp63 achieve tighter transcriptional regulation in quality control by converting an inhibitory element into an additional transactivation domain. Cell Death Dis. 2019;10 (10):686. doi: 10.1038/s41419-019-1936-z. PubMed PMID:31527723 PubMed Central PMC6746776.
  10. Soares, E, Xu, Q, Li, Q, Qu, J, Zheng, Y, Raeven, HHM et al.. Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome. Proc Natl Acad Sci U S A. 2019;116 (35):17361-17370. doi: 10.1073/pnas.1908180116. PubMed PMID:31413199 PubMed Central PMC6717277.
  11. Cox, TC, Lidral, AC, McCoy, JC, Liu, H, Cox, LL, Zhu, Y et al.. Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans. Hum Mutat. 2019;40 (10):1813-1825. doi: 10.1002/humu.23793. PubMed PMID:31215115 PubMed Central PMC6764866.
  12. Qu, J, Yi, G, Zhou, H. p63 cooperates with CTCF to modulate chromatin architecture in skin keratinocytes. Epigenetics Chromatin. 2019;12 (1):31. doi: 10.1186/s13072-019-0280-y. PubMed PMID:31164150 PubMed Central PMC6547520.
  13. Khandelwal, KD, van den Boogaard, MH, Mehrem, SL, Gebel, J, Fagerberg, C, van Beusekom, E et al.. Deletions and loss-of-function variants in TP63 associated with orofacial clefting. Eur J Hum Genet. 2019;27 (7):1101-1112. doi: 10.1038/s41431-019-0370-0. PubMed PMID:30850703 PubMed Central PMC6777535.
  14. Qu, J, Tanis, SEJ, Smits, JPH, Kouwenhoven, EN, Oti, M, van den Bogaard, EH et al.. Mutant p63 Affects Epidermal Cell Identity through Rewiring the Enhancer Landscape. Cell Rep. 2018;25 (12):3490-3503.e4. doi: 10.1016/j.celrep.2018.11.039. PubMed PMID:30566872 .
  15. Yang, B, Wang, Y, Guo, B, Jing, M, Zhou, H, Li, Y et al.. The Phytophthora sojae RXLR effector Avh238 destabilizes soybean Type2 GmACSs to suppress ethylene biosynthesis and promote infection. New Phytol. 2019;222 (1):425-437. doi: 10.1111/nph.15581. PubMed PMID:30394556 .
  16. Tanis, SEJ, Jansen, PWTC, Zhou, H, van Heeringen, SJ, Vermeulen, M, Kretz, M et al.. Splicing and Chromatin Factors Jointly Regulate Epidermal Differentiation. Cell Rep. 2018;25 (5):1292-1303.e5. doi: 10.1016/j.celrep.2018.10.017. PubMed PMID:30380419 .
  17. Karjosukarso, DW, van Gestel, SHC, Qu, J, Kouwenhoven, EN, Duijkers, L, Garanto, A et al.. An FEVR-associated mutation in ZNF408 alters the expression of genes involved in the development of vasculature. Hum Mol Genet. 2018;27 (20):3519-3527. doi: 10.1093/hmg/ddy244. PubMed PMID:29982478 .
  18. Roux, LN, Petit, I, Domart, R, Concordet, JP, Qu, J, Zhou, H et al.. Modeling of Aniridia-Related Keratopathy by CRISPR/Cas9 Genome Editing of Human Limbal Epithelial Cells and Rescue by Recombinant PAX6 Protein. Stem Cells. 2018;36 (9):1421-1429. doi: 10.1002/stem.2858. PubMed PMID:29808941 .
  19. Cox, LL, Cox, TC, Moreno Uribe, LM, Zhu, Y, Richter, CT, Nidey, N et al.. Mutations in the Epithelial Cadherin-p120-Catenin Complex Cause Mendelian Non-Syndromic Cleft Lip with or without Cleft Palate. Am J Hum Genet. 2018;102 (6):1143-1157. doi: 10.1016/j.ajhg.2018.04.009. PubMed PMID:29805042 PubMed Central PMC5992119.
  20. Iacono, G, Dubos, A, Méziane, H, Benevento, M, Habibi, E, Mandoli, A et al.. Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome. Nucleic Acids Res. 2018;46 (10):4950-4965. doi: 10.1093/nar/gky196. PubMed PMID:29554304 PubMed Central PMC6007260.
  21. Arcidiacono, P, Webb, CM, Brooke, MA, Zhou, H, Delaney, PJ, Ng, KE et al.. p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. Nat Commun. 2018;9 (1):1021. doi: 10.1038/s41467-018-03470-y. PubMed PMID:29523849 PubMed Central PMC5844915.
  22. Compagnone, M, Gatti, V, Presutti, D, Ruberti, G, Fierro, C, Markert, EK et al.. ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis. Proc Natl Acad Sci U S A. 2017;114 (50):13254-13259. doi: 10.1073/pnas.1711777114. PubMed PMID:29162693 PubMed Central PMC5740608.
  23. Soares, E, Zhou, H. Master regulatory role of p63 in epidermal development and disease. Cell Mol Life Sci. 2018;75 (7):1179-1190. doi: 10.1007/s00018-017-2701-z. PubMed PMID:29103147 PubMed Central PMC5843667.
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  26. Khandelwal, KD, Ockeloen, CW, Venselaar, H, Boulanger, C, Brichard, B, Sokal, E et al.. Identification of a de novo variant in CHUK in a patient with an EEC/AEC syndrome-like phenotype and hypogammaglobulinemia. Am J Med Genet A. 2017;173 (7):1813-1820. doi: 10.1002/ajmg.a.38274. PubMed PMID:28513979 .
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