On Tuesday November 17, 2015, dr. Lucas Pelkman from the Institute of Molecular Life Sciences of the University of Zurich (Switzerland) will give a presentation entitled “Origins of cellular heterogeneity” at 14.00 in the Figdor Lecture theatre on the 8th floor of the RIMLS building.
Cells do not operate in isolation, but create heterogeneous social contexts, to which they adapt their phenotypic behavior. This is true for single-cell organisms as well as for cells from multicellular organisms. The effect of this type of cell-to-cell variability on shaping the phenotypic spectrum of single cells has major consequences for how we study cellular processes and interpret molecular mechanisms and activities in single cells. It also shows that basic social properties of mammalian cells can be studied in in vitro experimental systems using cells grown in culture.
Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour. Nature; 523:88-91, 2015
A hierarchical map of regulatory genetic interactions in membrane trafficking. Cell; 157:1473-87, 2014
Image-based transcriptomics in thousands of single human cells at single-molecule resolution. Nat Methods; 10:1127-33, 2013