3 publications in Science

BLUEPRINT Sept 2014 kl
In the September issue of Science, 3 papers from the BLUEPRINT consortium are published. BLUEPRINT is a large-scale research project receiving close to 30 million euro funding from the EU. Henk Stunnenberg is coordinating this consortium consisting of 39 leading European universities, research institutes and industry entrepreneurs. All 3 papers describe research which had an important input from the department of Molecular Biology.
1. mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
2. Transcriptional diversity during lineage commitment of human blood progenitors
3. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Dutch Chromatin Meeting 2015 in Nijmegen

This year, the annual Dutch Chromatin Meeting will be held in Nijmegen on the 22nd of October.
We have arranged a program including two international keynote lectures, two national invited speakers and plenty of opportunities for selected talks from abstracts.

More information on the location, the program and the sponsors can be found on the following website:
http://www.rimls.nl/symposia/dutch-chromatin-meeting-2015

Registration for this meeting is free, but is required for attendance.

Submitting an abstract for a talk or a poster can be done exclusively through the website (deadline is the 1st of October).
A link to the abstract submission page will be send to you automatically after registering for the meeting.
We encourage all the group leaders to have their Phd-students and Post-docs submit abstracts of their best ongoing work.

We look forward to another great Dutch Chromatin Meeting with many active participants.

The organising committee,
Jo Zhou
Michiel Vermeulen
Klaas Mulder

Seminar Markus Elsner – Wednesday February 16, 2016 (14.00, LIN3, Linnaeus Building)

On Wednesday February 16, 2016, dr. Markus Elsner, senior editor at Nature Biotechnology, will give a presentation entitled “Nature Journals: an insiders perspective” at 14.00 in room LIN3 of the Linnaeus Building (Heyendaalseweg 137, Nijmegen).

Markus Elsner

Markus did his graduate work at EMBL in Heidelberg (Germany) and at the University of Gothenburg (Sweden), where he worked on characterizing protein dynamics in living cells. In his postdoctoral studies at the National Institutes of Health (USA), he investigated the mechanisms of lipid and protein sorting during membrane transport events. He joined Nature Biotechnology in 2008.

Seminar Jan Huisken – Tuesday January 12, 2016 (13.00, 8th floor RIMLS)

On Tuesday January 12, 2016, dr. Jan Huisken from the Max Planck Institute (MPI-CBG) Dresden (Germany) will give a presentation entitled “Reconstructing zebrafish development with smart light sheet microscopy” at 13.00 in the Figdor Lecture theatre on the 8th floor of the RIMLS building.

huisken

The overall goal in the Huisken lab is the systematic study of developmental processes in living organisms by noninvasive biomedical imaging techniques such as optical microscopy. Of primary interest is the investigation of organogenesis in zebrafish with special emphasis on the function and morphogenesis of the cardiovascular system and the endoderm. We develop novel quantitative microscopy tools and experimental strategies to understand and describe tissue dynamics on a cellular level. High-speed fluorescence microscopy is the primary tool to capture the dynamics of a heartbeat and the fate of single cells during organogenesis.

Seminar Lucas Pelkman – Tuesday November 17, 2015 (14.00, 8th floor RIMLS)

On Tuesday November 17, 2015, dr. Lucas Pelkman from the Institute of Molecular Life Sciences of the University of Zurich (Switzerland) will give a presentation entitled “Origins of cellular heterogeneity” at 14.00 in the Figdor Lecture theatre on the 8th floor of the RIMLS building.

lucas Pelkman

Cells do not operate in isolation, but create heterogeneous social contexts, to which they adapt their phenotypic behavior. This is true for single-cell organisms as well as for cells from multicellular organisms. The effect of this type of cell-to-cell variability on shaping the phenotypic spectrum of single cells has major consequences for how we study cellular processes and interpret molecular mechanisms and activities in single cells. It also shows that basic social properties of mammalian cells can be studied in in vitro experimental systems using cells grown in culture.

Key publications:

Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour. Nature; 523:88-91, 2015
A hierarchical map of regulatory genetic interactions in membrane trafficking. Cell; 157:1473-87, 2014
Image-based transcriptomics in thousands of single human cells at single-molecule resolution. Nat Methods; 10:1127-33, 2013