On December 18th, 2014, Dirk Schubeler will give a presentation entitled “The genetics of epigenetics” at 16.00 in the Figdor Lecture Theatre on the 8th floor of the RIMLS building. Following the lecture, drinks and snacks will be available to socialise with the lecturer and collegues.
Dirk Schübeler is a Senior Group Leader at the Friedrich Miescher Institute for Biomedical Research in Basel. His group studies the role of epigenetic modifications of DNA and nucleosomes in transcriptional regulation and genome maintenance. A particular interest is the role of epigenetic regulation in stabilizing transcriptional programs in defined cellular states and how it relates to the developmental potential of a given cell. The regulation of pluripotency of stem cells and their epigenetic reprogramming during differentiation provide important models to address these questions. To understand how stem cell maintenance and loss of pluripotency are regulated via chromatin and DNA methylation the group develops and applies functional genomics approaches. With these quantitative measures of the epigenome are performed to identify regulatory patterns and their function in cell fate decisions.
Dirk Schübeler is an elected member of the European Network of Excellence “The epigenome”, an EMBO Young Investigator and member of the Swiss Systems Biology initiative on Cell Plasticity.
On December 16th, 2014 12:00 hrs. – 13:00 dr. Pim Huis in ‘t Veld, IMP, Research Institute of Molecular Pathology, Vienna, Austria will give a seminar on “Characterization of a DNA exit gate in the human cohesion ring” in the Figdor Lecture Theatre, 8th floor RIMLS Building.
Chromosome segregation depends on sister chromatid cohesion mediated by cohesin. Cohesin’s Smc1, Smc3 and Scc1 subunits form tripartite rings that are thought to open at distinct sites to allow entry and exit of DNA. However, direct evidence for the existence of open forms of cohesin is lacking. Here we show that cohesin’s proposed DNA exit gate is formed by interactions between Scc1 and the coiled-coil region of Smc3. Mutation of this interface abolished cohesin’s ability to stably associate with chromatin and to mediate cohesion. Electron microscopy revealed that weakening of the Smc3-Scc1 interface, as well as proteolytic cleavage of Scc1, resulted in opening of cohesin rings. These open forms may resemble intermediate states of cohesin normally generated by the release factor Wapl and the protease separase, respectively.
As part of the ‘Molecular Principles of Development and Disease’ seminar series, Dr. Duncan Odom is visiting our departments.
He will meet with the PhD students over lunch and will present a seminar on ‘Enhancer evolution in twenty mammals’ at 14:00 on the 8th floor lecture theatre of the RIMLS building.
Duncan Odom, group leader, Cambridge Research Institute, Cambridge, UK, compares how transcription and transcriptional regulation vary during evolution, and the implications this regulatory plasticity has for diseases such as cancer. His team uses numerous new high-throughput methods combined with analysis of multiple mammals and vertebrates to reveal fundamental biological insights into tissue-specification and genome evolution.