All posts by Marion Bussemakers

Vacancy PhD student ‘Transcription circuitry and hierarchy controlling epithelial development and disease using integrative multi-omics approaches’

Brief project description

The aim of this project is to identify the key transcriptional circuitry that determines epithelial cell fates, specifically of epidermal and corneal limbal cells. As p63 is a key regulator of epidermal and corneal development and disease, this project takes a p63-centered approach to identify the transcription factors and their hierarchy in these stratified epithelia.

Responsibilities

  • Perform analyses of transcriptomics, epigenomics (ChIP-seq and ATAC-seq), proteomics in combination with computational modeling (supported by our computational experts)
  • Use mature epidermal keratinocytes, corneal limbal/epithelial cells and the induced pluripotent stem cell (iPSC) differentiation as the cellular models for the multi-omics analyses
  • Integrate these multi-omics data to identify the key transcription factors and their hierarchy Single-cell approaches such as single-cell RNA-seq may also be used in the project
  • Have the opportunity to develop novel ideas and work on an independent project that aligns with our research interests

Qualifications

  • A master degree in molecular or cellular biology, molecular life sciences or related field.
  • Experience in in one or more of the following areas: molecular biology and cell biology techniques, generation and analysis of Next Generation Sequencing data, single cell approaches, (mammalian) genomics and gene regulation
  • Experience in stem cell culture and/or computational analysis is preferred but not required
  • Excellent communication skills in written and spoken English
  • Strong analytical skills, a problem-solving and an result-oriented attitude
  • The ability to work and interact with others in an energetic and supportive research environment
  • Highly motivated and ambitious

Work environment

The PhD student will join our research team in the Department of Molecular Developmental Biology, located at the Radboud Institute for Molecular Life Sciences (RIMLS), Faculty of Science in Nijmegen, the Netherlands. We offer a first class international research environment in regulation of gene expression and epigenetics using state-of-the-art genomic and proteomic technologies and bioinformatics. We run Next-Generation Sequencers, single cell equipment, Mass Spectrometers and accommodate a bioinformatics team and a local computational infrastructure.

The Radboud University Faculty of Science is an equal opportunity employer, committed to building a culturally diverse intellectual community, and as such encourages applications from women and minorities.

Further information and how to apply

Exceptionally Excellent Prize’ from China for Shuangyin Wang as a Chinese PhD student studied abroad

Shuangyin Wang, a PhD student who recently finished his PhD study in Professor Henk Stunnenberg’s lab, has received a prestigious prize from the Chinese government for excellent PhD students abroad. This prize is for the best 500 Chinese PhD students who obtained scholarships from foreign universities and institutes and worked or are working for their PhD studies outside China. Among this year’s 500 students worldwide, Shuangyin Wang ranked number 1 and therefore received the ‘Exceptionally Excellent Prize’ and US$10,000 for his achievement. On 20th April, Shuangyin Wang, his PhD supervisor Henk Stunnenberg and the president of Radboud University Daniël Wigboldus attended the ceremony in the Chinese Embassy in the Hague to receive this prize. Shuangyin Wang is current doing his postdoctoral training in the Weizmann Institute in Israel.

Shuangyin Wang
Shuangyin Wang

Vacancy Postdoc ‘Single cell analysis to unveil the interplay of colorectal cancer and immune cells’

Project

The post-doctoral researcher will be working in an inspiring and collaborative research environment. This ambitious project aims to define the quantitative molecular signature of tissue resident immune cells in healthy tissue and in colorectal cancer cells.  Using single cell approaches combined with imaging, spatial transcriptomics and bioinformatic approaches, you will unveil the topology of the tissue and tumor and define the interplay the immune cells with the surrounding cancer and stromal cells.

What we expect:

  • A PhD in molecular or cellular biology, molecular life sciences, bioinformatics or related fields.
  • Experience with state-of-the-art molecular biology, single cell transcriptome or Imaging
  • Strong analytical skills, a problem-solving and a result-oriented attitude
  • Creative and innovative thinking and a high degree of independence

Work environment

The highly motivated and ambitious post-docs will join our internationally renowned research team in the Department of Molecular Biology, located at the Radboud Institute for Molecular Life Sciences (RIMLS), Faculty of Science in Nijmegen, the Netherlands. We offer a first-class international research environment in regulation of gene expression and epigenetics using state-of-the-art genomic, single cell analysis, proteomic technologies and bioinformatics. We run our own Next-Generation Sequencers, Single cell equipment, Mass Spectrometers and we accommodate a bioinformatics team and a local computational infrastructure.

Duration: 2 years with the option of an extension

Further information and how to apply: