Resources

Bioinformatics tools:

p53/p63 motif scan (Kouwenhoven et al., 2010 PLoS Genetics, PMID:20808887)

https://github.com/simonvh/p53scan/blob/master/dist/p53scan-1.05.win32-py2.7.zip?raw=true

supporting program

https://www.python.org/download/releases/2.7.5/

Open datasets:

Gene Expression Omnibus accession number GSE98483 

Gene Expression Omnibus accession number GSE120107

Genotypes and Phenotypes (dbGaP) database accession number phs001737.v2.p1

Mutant p63 Affects Epidermal Cell Identity through Rewiring the Enhancer Landscape. Cell Rep. 2018 Dec 18;25(12):3490-3503.e4. PMID:30566872

Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome. Proc. Natl. Acad. Sci. U.S.A. 2019. PMID:31413199

Gene Expression Omnibus accession number GSE59827

Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation. EMBO Rep. (2015) 16(7):863-78. PMID:26034101

Gene Expression Omnibus accession number GSE17611

Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus. PLoS Genetics 6, e1001065 PMID:20808887

Gene Expression Omnibus accession number GSE46833 

De novo mutations in the genome organizer CTCF cause intellectual disability.  Am J Hum Genet. (2013) 93(1):124-31. PMID:23746550

Gene Expression Omnibus accession number GSE79860

Transcriptome Analysis Identifies Multifaceted Regulatory Mechanisms Dictating a Genetic Switch from Neuronal Network Establishment to Maintenance During Postnatal Prefrontal Cortex Development. Cereb. Cortex. 2017. PMID:28108491