Publications

  1. Richardson, R, Mitchell, K, Hammond, NL, Mollo, MR, Kouwenhoven, EN, Wyatt, ND et al.. p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017;13 (6):e1006828. doi: 10.1371/journal.pgen.1006828. PubMed PMID:28604778 PubMed Central PMC5484519.
  2. Khandelwal, KD, Ockeloen, CW, Venselaar, H, Boulanger, C, Brichard, B, Sokal, E et al.. Identification of a de novo variant in CHUK in a patient with an EEC/AEC syndrome-like phenotype and hypogammaglobulinemia. Am. J. Med. Genet. A. 2017; :. doi: 10.1002/ajmg.a.38274. PubMed PMID:28513979 .
  3. Sethi, I, Gluck, C, Zhou, H, Buck, MJ, Sinha, S. Evolutionary re-wiring of p63 and the epigenomic regulatory landscape in keratinocytes and its potential implications on species-specific gene expression and phenotypes. Nucleic Acids Res. 2017;45 (14):8208-8224. doi: 10.1093/nar/gkx416. PubMed PMID:28505376 .
  4. Ngcungcu, T, Oti, M, Sitek, JC, Haukanes, BI, Linghu, B, Bruccoleri, R et al.. Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families. Am. J. Hum. Genet. 2017;100 (5):737-750. doi: 10.1016/j.ajhg.2017.03.012. PubMed PMID:28457472 PubMed Central PMC5420352.
  5. Kroeze, Y, Oti, M, van Beusekom, E, Cooijmans, RH, van Bokhoven, H, Kolk, SM et al.. Transcriptome Analysis Identifies Multifaceted Regulatory Mechanisms Dictating a Genetic Switch from Neuronal Network Establishment to Maintenance During Postnatal Prefrontal Cortex Development. Cereb. Cortex. 2017; :. doi: 10.1093/cercor/bhw407. PubMed PMID:28108491 .
  6. Khandelwal, KD, Ishorst, N, Zhou, H, Ludwig, KU, Venselaar, H, Gilissen, C et al.. Novel IRF6 Mutations Detected in Orofacial Cleft Patients by Targeted Massively Parallel Sequencing. J. Dent. Res. 2017;96 (2):179-185. doi: 10.1177/0022034516678829. PubMed PMID:27834299 .
  7. Ockeloen, CW, Khandelwal, KD, Dreesen, K, Ludwig, KU, Sullivan, R, van Rooij, IALM et al.. Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesis. Genet. Med. 2016;18 (11):1158-1162. doi: 10.1038/gim.2016.10. PubMed PMID:26963285 PubMed Central PMC5018235.
  8. Phan, M, Conte, F, Khandelwal, KD, Ockeloen, CW, Bartzela, T, Kleefstra, T et al.. Tooth agenesis and orofacial clefting: genetic brothers in arms?. Hum. Genet. 2016;135 (12):1299-1327. doi: 10.1007/s00439-016-1733-z. PubMed PMID:27699475 PubMed Central PMC5065589.
  9. Benevento, M, Iacono, G, Selten, M, Ba, W, Oudakker, A, Frega, M et al.. Histone Methylation by the Kleefstra Syndrome Protein EHMT1 Mediates Homeostatic Synaptic Scaling. Neuron. 2016;91 (2):341-55. doi: 10.1016/j.neuron.2016.06.003. PubMed PMID:27373831 .
  10. Mammadova, A, Zhou, H, Carels, CE, Von den Hoff, JW. Retinoic acid signalling in the development of the epidermis, the limbs and the secondary palate. Differentiation. 2016;92 (5):326-335. doi: 10.1016/j.diff.2016.05.001. PubMed PMID:27238416 .
  11. Kroeze, Y, Dirven, B, Janssen, S, Kröhnke, M, Barte, RM, Middelman, A et al.. Perinatal reduction of functional serotonin transporters results in developmental delay. Neuropharmacology. 2016;109 :96-111. doi: 10.1016/j.neuropharm.2016.05.012. PubMed PMID:27208789 .
  12. Kroeze, Y, Peeters, D, Boulle, F, van den Hove, DL, van Bokhoven, H, Zhou, H et al.. Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus. Transl Psychiatry. 2016;6 :e779. doi: 10.1038/tp.2016.60. PubMed PMID:27070407 PubMed Central PMC4872416.
  13. Oti, M, Falck, J, Huynen, MA, Zhou, H. CTCF-mediated chromatin loops enclose inducible gene regulatory domains. BMC Genomics. 2016;17 :252. doi: 10.1186/s12864-016-2516-6. PubMed PMID:27004515 PubMed Central PMC4804521.
  14. Conte, F, Oti, M, Dixon, J, Carels, CE, Rubini, M, Zhou, H et al.. Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts. Hum. Genet. 2016;135 (1):41-59. doi: 10.1007/s00439-015-1606-x. PubMed PMID:26561393 PubMed Central PMC4698300.
  15. Oti, M, Kouwenhoven, EN, Zhou, H. Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes. Genom Data. 2015;5 :159-63. doi: 10.1016/j.gdata.2015.06.002. PubMed PMID:26484246 PubMed Central PMC4584025.
  16. Brouwer, M, Zhou, H, Nadif Kasri, N. Choices for Induction of Pluripotency: Recent Developments in Human Induced Pluripotent Stem Cell Reprogramming Strategies. Stem Cell Rev. 2016;12 (1):54-72. doi: 10.1007/s12015-015-9622-8. PubMed PMID:26424535 PubMed Central PMC4720703.
  17. Kroeze, Y, Peeters, D, Boulle, F, Pawluski, JL, van den Hove, DL, van Bokhoven, H et al.. Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus. Transl Psychiatry. 2015;5 :e642. doi: 10.1038/tp.2015.145. PubMed PMID:26393488 PubMed Central PMC5068807.
  18. Viticchiè, G, Agostini, M, Lena, AM, Mancini, M, Zhou, H, Zolla, L et al.. p63 supports aerobic respiration through hexokinase II. Proc. Natl. Acad. Sci. U.S.A. 2015;112 (37):11577-82. doi: 10.1073/pnas.1508871112. PubMed PMID:26324887 PubMed Central PMC4577137.
  19. Giacobbe, A, Compagnone, M, Bongiorno-Borbone, L, Antonov, A, Markert, EK, Zhou, JH et al.. p63 controls cell migration and invasion by transcriptional regulation of MTSS1. Oncogene. 2016;35 (12):1602-8. doi: 10.1038/onc.2015.230. PubMed PMID:26119942 .
  20. Kouwenhoven, EN, Oti, M, Niehues, H, van Heeringen, SJ, Schalkwijk, J, Stunnenberg, HG et al.. Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation. EMBO Rep. 2015;16 (7):863-78. doi: 10.15252/embr.201439941. PubMed PMID:26034101 PubMed Central PMC4515125.
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