Publications

  1. Toenhake, CG, Fraschka, SA, Vijayabaskar, MS, Westhead, DR, van Heeringen, SJ, Bártfai, R et al.. Chromatin Accessibility-Based Characterization of the Gene Regulatory Network Underlying Plasmodium falciparum Blood-Stage Development. Cell Host Microbe. 2018;23 (4):557-569.e9. doi: 10.1016/j.chom.2018.03.007. PubMed PMID:29649445 PubMed Central PMC5899830.
  2. Filarsky, M, Fraschka, SA, Niederwieser, I, Brancucci, NMB, Carrington, E, Carrió, E et al.. GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing. Science. 2018;359 (6381):1259-1263. doi: 10.1126/science.aan6042. PubMed PMID:29590075 PubMed Central PMC6219702.
  3. Fraschka, SA, Filarsky, M, Hoo, R, Niederwieser, I, Yam, XY, Brancucci, NMB et al.. Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites. Cell Host Microbe. 2018;23 (3):407-420.e8. doi: 10.1016/j.chom.2018.01.008. PubMed PMID:29503181 PubMed Central PMC5853956.
  4. Hoeijmakers, WAM, Bártfai, R. Characterization of the Nucleosome Landscape by Micrococcal Nuclease-Sequencing (MNase-seq). Methods Mol. Biol. 2018;1689 :83-101. doi: 10.1007/978-1-4939-7380-4_8. PubMed PMID:29027167 .
  5. Bertschi, NL, Toenhake, CG, Zou, A, Niederwieser, I, Henderson, R, Moes, S et al.. Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA. Nat Microbiol. 2017;2 :17033. doi: 10.1038/nmicrobiol.2017.33. PubMed PMID:28288093 .
  6. Fraschka, SA, Henderson, RW, Bártfai, R. H3.3 demarcates GC-rich coding and subtelomeric regions and serves as potential memory mark for virulence gene expression in Plasmodium falciparum. Sci Rep. 2016;6 :31965. doi: 10.1038/srep31965. PubMed PMID:27555062 PubMed Central PMC4995406.
  7. Lasonder, E, Rijpma, SR, van Schaijk, BC, Hoeijmakers, WA, Kensche, PR, Gresnigt, MS et al.. Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression. Nucleic Acids Res. 2016;44 (13):6087-101. doi: 10.1093/nar/gkw536. PubMed PMID:27298255 PubMed Central PMC5291273.
  8. Kensche, PR, Hoeijmakers, WA, Toenhake, CG, Bras, M, Chappell, L, Berriman, M et al.. The nucleosome landscape of Plasmodium falciparum reveals chromatin architecture and dynamics of regulatory sequences. Nucleic Acids Res. 2016;44 (5):2110-24. doi: 10.1093/nar/gkv1214. PubMed PMID:26578577 PubMed Central PMC4797266.
  9. Voss, TS, Bozdech, Z, Bártfai, R. Epigenetic memory takes center stage in the survival strategy of malaria parasites. Curr. Opin. Microbiol. 2014;20 :88-95. doi: 10.1016/j.mib.2014.05.007. PubMed PMID:24945736 .
  10. Hoeijmakers, WA, Salcedo-Amaya, AM, Smits, AH, Françoijs, KJ, Treeck, M, Gilberger, TW et al.. H2A.Z/H2B.Z double-variant nucleosomes inhabit the AT-rich promoter regions of the Plasmodium falciparum genome. Mol. Microbiol. 2013;87 (5):1061-73. doi: 10.1111/mmi.12151. PubMed PMID:23320541 PubMed Central PMC3594968.
  11. Hoeijmakers, WA, Stunnenberg, HG, Bártfai, R. Placing the Plasmodium falciparum epigenome on the map. Trends Parasitol. 2012;28 (11):486-95. doi: 10.1016/j.pt.2012.08.006. PubMed PMID:22999479 .
  12. Hoeijmakers, WA, Bártfai, R, Stunnenberg, HG. Transcriptome analysis using RNA-Seq. Methods Mol. Biol. 2013;923 :221-39. doi: 10.1007/978-1-62703-026-7_15. PubMed PMID:22990781 .
  13. Hoeijmakers, WA, Flueck, C, Françoijs, KJ, Smits, AH, Wetzel, J, Volz, JC et al.. Plasmodium falciparum centromeres display a unique epigenetic makeup and cluster prior to and during schizogony. Cell. Microbiol. 2012;14 (9):1391-401. doi: 10.1111/j.1462-5822.2012.01803.x. PubMed PMID:22507744 .
  14. Volz, JC, Bártfai, R, Petter, M, Langer, C, Josling, GA, Tsuboi, T et al.. PfSET10, a Plasmodium falciparum methyltransferase, maintains the active var gene in a poised state during parasite division. Cell Host Microbe. 2012;11 (1):7-18. doi: 10.1016/j.chom.2011.11.011. PubMed PMID:22264509 .
  15. Laurentino, EC, Taylor, S, Mair, GR, Lasonder, E, Bartfai, R, Stunnenberg, HG et al.. Experimentally controlled downregulation of the histone chaperone FACT in Plasmodium berghei reveals that it is critical to male gamete fertility. Cell. Microbiol. 2011;13 (12):1956-74. doi: 10.1111/j.1462-5822.2011.01683.x. PubMed PMID:21899698 PubMed Central PMC3429858.
  16. Hoeijmakers, WA, Bártfai, R, Françoijs, KJ, Stunnenberg, HG. Linear amplification for deep sequencing. Nat Protoc. 2011;6 (7):1026-36. doi: 10.1038/nprot.2011.345. PubMed PMID:21720315 .
  17. Richard, D, Bartfai, R, Volz, J, Ralph, SA, Muller, S, Stunnenberg, HG et al.. A genome-wide chromatin-associated nuclear peroxiredoxin from the malaria parasite Plasmodium falciparum. J. Biol. Chem. 2011;286 (13):11746-55. doi: 10.1074/jbc.M110.198499. PubMed PMID:21282103 PubMed Central PMC3064226.
  18. Bártfai, R, Hoeijmakers, WA, Salcedo-Amaya, AM, Smits, AH, Janssen-Megens, E, Kaan, A et al.. H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3. PLoS Pathog. 2010;6 (12):e1001223. doi: 10.1371/journal.ppat.1001223. PubMed PMID:21187892 PubMed Central PMC3002978.
  19. Salcedo-Amaya, AM, Hoeijmakers, WA, Bártfai, R, Stunnenberg, HG. Malaria: could its unusual epigenome be the weak spot?. Int. J. Biochem. Cell Biol. 2010;42 (6):781-4. doi: 10.1016/j.biocel.2010.03.010. PubMed PMID:20303414 .
  20. Flueck, C, Bartfai, R, Niederwieser, I, Witmer, K, Alako, BT, Moes, S et al.. A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology. PLoS Pathog. 2010;6 (2):e1000784. doi: 10.1371/journal.ppat.1000784. PubMed PMID:20195509 PubMed Central PMC2829057.
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