Publications

  1. Lindeboom, RGH, Vermeulen, M, Lehner, B, Supek, F. The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy. Nat. Genet. 2019;51 (11):1645-1651. doi: 10.1038/s41588-019-0517-5. PubMed PMID:31659324 PubMed Central PMC6858879.
  2. Bonnet, J, Lindeboom, RGH, Pokrovsky, D, Stricker, G, Çelik, MH, Rupp, RAW et al.. Quantification of Proteins and Histone Marks in Drosophila Embryos Reveals Stoichiometric Relationships Impacting Chromatin Regulation. Dev. Cell. 2019; :. doi: 10.1016/j.devcel.2019.09.011. PubMed PMID:31630981 .
  3. Healy, E, Mucha, M, Glancy, E, Fitzpatrick, DJ, Conway, E, Neikes, HK et al.. PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation. Mol. Cell. 2019;76 (3):437-452.e6. doi: 10.1016/j.molcel.2019.08.012. PubMed PMID:31521505 .
  4. Rougeot, J, Chrispijn, ND, Aben, M, Elurbe, DM, Andralojc, KM, Murphy, PJ et al.. Maintenance of spatial gene expression by Polycomb-mediated repression after formation of a vertebrate body plan. Development. 2019;146 (19):. doi: 10.1242/dev.178590. PubMed PMID:31488564 PubMed Central PMC6803366.
  5. Ragazzini, R, Pérez-Palacios, R, Baymaz, IH, Diop, S, Ancelin, K, Zielinski, D et al.. EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells. Nat Commun. 2019;10 (1):3858. doi: 10.1038/s41467-019-11800-x. PubMed PMID:31451685 PubMed Central PMC6710278.
  6. van Arensbergen, J, Pagie, L, FitzPatrick, VD, de Haas, M, Baltissen, MP, Comoglio, F et al.. High-throughput identification of human SNPs affecting regulatory element activity. Nat. Genet. 2019;51 (7):1160-1169. doi: 10.1038/s41588-019-0455-2. PubMed PMID:31253979 PubMed Central PMC6609452.
  7. van Mierlo, G, Veenstra, GJC, Vermeulen, M, Marks, H. The Complexity of PRC2 Subcomplexes. Trends Cell Biol. 2019;29 (8):660-671. doi: 10.1016/j.tcb.2019.05.004. PubMed PMID:31178244 .
  8. Hoek, TA, Khuperkar, D, Lindeboom, RGH, Sonneveld, S, Verhagen, BMP, Boersma, S et al.. Single-Molecule Imaging Uncovers Rules Governing Nonsense-Mediated mRNA Decay. Mol. Cell. 2019;75 (2):324-339.e11. doi: 10.1016/j.molcel.2019.05.008. PubMed PMID:31155380 PubMed Central PMC6675935.
  9. Artegiani, B, van Voorthuijsen, L, Lindeboom, RGH, Seinstra, D, Heo, I, Tapia, P et al.. Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids. Cell Stem Cell. 2019;24 (6):927-943.e6. doi: 10.1016/j.stem.2019.04.017. PubMed PMID:31130514 .
  10. Ignatova, VV, Jansen, PWTC, Baltissen, MP, Vermeulen, M, Schneider, R. The interactome of a family of potential methyltransferases in HeLa cells. Sci Rep. 2019;9 (1):6584. doi: 10.1038/s41598-019-43010-2. PubMed PMID:31036863 PubMed Central PMC6488577.
  11. Burgold, T, Barber, M, Kloet, S, Cramard, J, Gharbi, S, Floyd, R et al.. The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment. EMBO J. 2019;38 (12):. doi: 10.15252/embj.2018100788. PubMed PMID:31036553 PubMed Central PMC6576150.
  12. Tracey, LJ, Brooke-Bisschop, T, Jansen, PWTC, Campos, EI, Vermeulen, M, Justice, MJ et al.. The Pluripotency Regulator PRDM14 Requires Hematopoietic Regulator CBFA2T3 to Initiate Leukemia in Mice. Mol. Cancer Res. 2019;17 (7):1468-1479. doi: 10.1158/1541-7786.MCR-18-1327. PubMed PMID:31015254 PubMed Central PMC6610658.
  13. Del Gaudio, N, Di Costanzo, A, Liu, NQ, Conte, L, Migliaccio, A, Vermeulen, M et al.. BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition. Cell Death Dis. 2019;10 (5):338. doi: 10.1038/s41419-019-1570-9. PubMed PMID:31000698 PubMed Central PMC6472371.
  14. Furlan, C, Dirks, RAM, Thomas, PC, Jones, RC, Wang, J, Lynch, M et al.. Miniaturised interaction proteomics on a microfluidic platform with ultra-low input requirements. Nat Commun. 2019;10 (1):1525. doi: 10.1038/s41467-019-09533-y. PubMed PMID:30948724 PubMed Central PMC6449397.
  15. Wassef, M, Luscan, A, Aflaki, S, Zielinski, D, Jansen, PWTC, Baymaz, HI et al.. EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer. Proc. Natl. Acad. Sci. U.S.A. 2019;116 (13):6075-6080. doi: 10.1073/pnas.1814634116. PubMed PMID:30867289 PubMed Central PMC6442582.
  16. Yi, G, Mandoli, A, Jussen, L, Tijchon, E, van Bergen, MGJM, Cordonnier, G et al.. CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1. Blood Cancer J. 2019;9 (3):33. doi: 10.1038/s41408-019-0194-8. PubMed PMID:30850577 PubMed Central PMC6408575.
  17. van Oorschot, R, Hansen, M, Koornneef, JM, Marneth, AE, Bergevoet, SM, van Bergen, MGJM et al.. Molecular mechanisms of bleeding disorderassociated GFI1BQ287* mutation and its affected pathways in megakaryocytes and platelets. Haematologica. 2019;104 (7):1460-1472. doi: 10.3324/haematol.2018.194555. PubMed PMID:30655368 PubMed Central PMC6601108.
  18. Joosten, J, Miesen, P, Taşköprü, E, Pennings, B, Jansen, PWTC, Huynen, MA et al.. The Tudor protein Veneno assembles the ping-pong amplification complex that produces viral piRNAs in Aedes mosquitoes. Nucleic Acids Res. 2019;47 (5):2546-2559. doi: 10.1093/nar/gky1266. PubMed PMID:30566680 PubMed Central PMC6411831.
  19. van Mierlo, G, Dirks, RAM, De Clerck, L, Brinkman, AB, Huth, M, Kloet, SL et al.. Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency. Cell Stem Cell. 2019;24 (1):123-137.e8. doi: 10.1016/j.stem.2018.10.017. PubMed PMID:30472157 .
  20. Brien, GL, Remillard, D, Shi, J, Hemming, ML, Chabon, J, Wynne, K et al.. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife. 2018;7 :. doi: 10.7554/eLife.41305. PubMed PMID:30431433 PubMed Central PMC6277197.
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