Publications

  1. Del Gaudio, N, Di Costanzo, A, Liu, NQ, Conte, L, Migliaccio, A, Vermeulen, M et al.. BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition. Cell Death Dis. 2019;10 (5):338. doi: 10.1038/s41419-019-1570-9. PubMed PMID:31000698 PubMed Central PMC6472371.
  2. Brinkman, AB, Nik-Zainal, S, Simmer, F, Rodríguez-González, FG, Smid, M, Alexandrov, LB et al.. Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation. Nat Commun. 2019;10 (1):1749. doi: 10.1038/s41467-019-09828-0. PubMed PMID:30988298 PubMed Central PMC6465362.
  3. Smid, M, Wilting, SM, Uhr, K, Rodríguez-González, FG, de Weerd, V, Prager-Van der Smissen, WJC et al.. The circular RNome of primary breast cancer. Genome Res. 2019;29 (3):356-366. doi: 10.1101/gr.238121.118. PubMed PMID:30692147 PubMed Central PMC6396421.
  4. Yi, G, Wierenga, ATJ, Petraglia, F, Narang, P, Janssen-Megens, EM, Mandoli, A et al.. Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes. Cell Rep. 2019;26 (4):1059-1069.e6. doi: 10.1016/j.celrep.2018.12.098. PubMed PMID:30673601 PubMed Central PMC6363099.
  5. Nik-Zainal, S, Davies, H, Staaf, J, Ramakrishna, M, Glodzik, D, Zou, X et al.. Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. 2019;566 (7742):E1. doi: 10.1038/s41586-019-0883-2. PubMed PMID:30659290 .
  6. Teo, K, Gómez-Cuadrado, L, Tenhagen, M, Byron, A, Rätze, M, van Amersfoort, M et al.. E-cadherin loss induces targetable autocrine activation of growth factor signalling in lobular breast cancer. Sci Rep. 2018;8 (1):15454. doi: 10.1038/s41598-018-33525-5. PubMed PMID:30337563 PubMed Central PMC6193986.
  7. Grassi, L, Pourfarzad, F, Ullrich, S, Merkel, A, Were, F, Carrillo-de-Santa-Pau, E et al.. Dynamics of Transcription Regulation in Human Bone Marrow Myeloid Differentiation to Mature Blood Neutrophils. Cell Rep. 2018;24 (10):2784-2794. doi: 10.1016/j.celrep.2018.08.018. PubMed PMID:30184510 PubMed Central PMC6326331.
  8. Søndergaard, JN, van Heeringen, SJ, Looman, MWG, Tang, C, Triantis, V, Louche, P et al.. Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions via DC-SCRIPT and Dual-Specificity Phosphatase 4. Front Immunol. 2018;9 :1420. doi: 10.3389/fimmu.2018.01420. PubMed PMID:29988341 PubMed Central PMC6023963.
  9. Singh, AA, Petraglia, F, Nebbioso, A, Yi, G, Conte, M, Valente, S et al.. Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia. Oncotarget. 2018;9 (39):25647-25660. doi: 10.18632/oncotarget.25429. PubMed PMID:29876014 PubMed Central PMC5986653.
  10. Petraglia, F, Singh, AA, Carafa, V, Nebbioso, A, Conte, M, Scisciola, L et al.. Combined HAT/EZH2 modulation leads to cancer-selective cell death. Oncotarget. 2018;9 (39):25630-25646. doi: 10.18632/oncotarget.25428. PubMed PMID:29876013 PubMed Central PMC5986654.
  11. Beekman, R, Chapaprieta, V, Russiñol, N, Vilarrasa-Blasi, R, Verdaguer-Dot, N, Martens, JHA et al.. The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia. Nat. Med. 2018;24 (6):868-880. doi: 10.1038/s41591-018-0028-4. PubMed PMID:29785028 PubMed Central PMC6363101.
  12. Dell'Aversana, C, Giorgio, C, D'Amato, L, Lania, G, Matarese, F, Saeed, S et al.. miR-194-5p/BCLAF1 deregulation in AML tumorigenesis. Leukemia. 2018;32 (2):573. doi: 10.1038/leu.2017.310. PubMed PMID:29271969 .
  13. Glodzik, D, Morganella, S, Davies, H, Simpson, PT, Li, Y, Zou, X et al.. Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers. Nat. Genet. 2017;49 (11):1661. doi: 10.1038/ng1117-1661a. PubMed PMID:29074948 .
  14. Nebbioso, A, Benedetti, R, Conte, M, Carafa, V, De Bellis, F, Shaik, J et al.. Time-resolved analysis of DNA-protein interactions in living cells by UV laser pulses. Sci Rep. 2017;7 (1):11725. doi: 10.1038/s41598-017-12010-5. PubMed PMID:28916762 PubMed Central PMC5601431.
  15. Marneth, AE, Prange, KHM, Al Hinai, ASA, Bergevoet, SM, Tesi, N, Janssen-Megens, EM et al.. C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation. Leukemia. 2018;32 (3):828-836. doi: 10.1038/leu.2017.280. PubMed PMID:28871137 .
  16. Petersen, R, Lambourne, JJ, Javierre, BM, Grassi, L, Kreuzhuber, R, Ruklisa, D et al.. Platelet function is modified by common sequence variation in megakaryocyte super enhancers. Nat Commun. 2017;8 :16058. doi: 10.1038/ncomms16058. PubMed PMID:28703137 PubMed Central PMC5511350.
  17. Ju, YS, Martincorena, I, Gerstung, M, Petljak, M, Alexandrov, LB, Rahbari, R et al.. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo. Nature. 2017;543 (7647):714-718. doi: 10.1038/nature21703. PubMed PMID:28329761 PubMed Central PMC6169740.
  18. Davies, H, Glodzik, D, Morganella, S, Yates, LR, Staaf, J, Zou, X et al.. HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. Nat. Med. 2017;23 (4):517-525. doi: 10.1038/nm.4292. PubMed PMID:28288110 PubMed Central PMC5833945.
  19. Dell'Aversana, C, Giorgio, C, D'Amato, L, Lania, G, Matarese, F, Saeed, S et al.. miR-194-5p/BCLAF1 deregulation in AML tumorigenesis. Leukemia. 2017;31 (11):2315-2325. doi: 10.1038/leu.2017.64. PubMed PMID:28216661 PubMed Central PMC5668498.
  20. Prange, KHM, Mandoli, A, Kuznetsova, T, Wang, SY, Sotoca, AM, Marneth, AE et al.. MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia. Oncogene. 2017;36 (23):3346-3356. doi: 10.1038/onc.2016.488. PubMed PMID:28114278 PubMed Central PMC5474565.
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