Molecular Biology

Our research aims at unravelling the molecular basis of development and differentiation emanating from the genome and epigenome in the context of health and disease. The major focus is on the regulatory networks in several model systems. State-of-the-art technological developments are applied ranging from single molecule studies to genome wide elucidation of genetic and epigenetic pathways and mechanisms. The lack of a quantitative framework around the dynamics of the epigenome and its determinants represents a major hurdle for the translation of epigenetic observations into regulatory models, for the identification of associations between epigenotypes and diseases and the subsequent development of an entire new class of compounds for their prevention and treatment. Next Generation Sequencing platforms are routinely used to analyse transcription factor binding sites, 3D structure, epigenetic marks, DNA-methylation and RNA transcriptomes at a comprehensive genome wide scale. Moreover, over the recent years, we set up a state-of-the-art quantitative mass-spectrometry based proteomics facility to integrate epigenomics and proteomics approaches. In depths analysis of the genome wide data is performed and sustained by our own bioinformatic team.

Research groups

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Head of department

Prof. Henk Stunnenberg
Full Professor of Molecular Biology